Association between initial lipid and lipoprotein levels, oxidative stress indicators and clinical efficacy of intravenous methylprednisolone in moderate-to-severe thyroid-associated ophthalmopathy: protocol for a real-world prospective cohort study.

ABSTRACT:

Background

Thyroid-associated ophthalmopathy (TAO), the most common orbital disease in adults, is an autoimmune disease of the orbital and periorbital tissues. Typical ocular symptoms of TAO include periorbital oedema, conjunctival congestion and oedema, eyelid retraction, exophthalmos, restrictive strabismus, etc. Hypercholesterolaemia is considered one of the modifiable risk factors of TAO. However, it is unclear whether lipid levels are related to TAO activity and severity and the intravenous glucocorticoids (GC) therapeutic effect. The study aims to evaluate the association between initial lipid and lipoprotein levels, the clinical features of TAO and the efficacy of intravenous methylprednisolone in patients with moderate-to-severe TAO, as well as to explore the oxidative stre

SUBMITTER: Liu S 

PROVIDER: S-EPMC12336564 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature