Nationwide survey of coeliac disease serology testing in the UK.

ABSTRACT:

Objective

Recent evidence supports diagnosing coeliac disease without biopsy in patients with significantly elevated tissue transglutaminase (IgA-tTG) antibodies. However, the implementation of this no-biopsy approach relies on accurate and consistent serological testing across laboratories. In this nationwide survey, we aimed to evaluate the availability and variability of coeliac disease testing across the UK.

Methods

We conducted a cross-sectional telephone survey of biomedical scientists and laboratory managers from National Health Service trusts and health boards across England, Wales, Scotland, and Northern Ireland. Data collected included assay types, reporting methods, upper limit of normal (ULN) thresholds, turnaround times, total IgA testing, and anti-endomysial an

SUBMITTER: Alex A 

PROVIDER: S-EPMC12336569 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature