Increased Thrombogenicity is Associated With Coronary Microvascular Dysfunction in Patients With STEMI-A Proof-of-Concept Study.

ABSTRACT:

Background

Up to 50% of patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) develop coronary microvascular dysfunction (CMD).

Aims

This study aims to assess whether a prothrombotic state of coronary blood, defined by thromboelastography (TEG), is associated with post-pPCI CMD in STEMI.

Methods

TEG analysis of infarct-related coronary artery (IRA) blood was performed in 25 consecutive STEMI patients before and after successful pPCI. CMD was defined by high values of the angiography-derived index of microcirculatory resistance (IMR_angio ≥ 40 units).

Results

The median age was 59 (IQR 51-71) years. CMD was observed in 13 (52%) patients. Pre-pPCI Reaction (R) and Kinetic (K) time o

SUBMITTER: Scarsini R 

PROVIDER: S-EPMC12336792 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature