Comprehensive analysis of disulfidoptosis-related genes reveals molecular heterogeneity and key regulators in retinoblastoma progression.

ABSTRACT:

Background

Disulfidoptosis, a newly recognised form of cell death, has been studied in many cancers but not in retinoblastoma. Therefore, this study aimed to investigate the role of disulfidoptosis-related genes (DRGs) in retinoblastoma.

Methods

Three retinoblastoma datasets (GSE208143, GSE97508, and GSE24673) were obtained from the Gene Expression Omnibus database. Differentially expressed DRGs (DE-DRGs) in retinoblastoma were identified, and key genes were screened using machine learning algorithms. Consensus cluster analysis was applied to identify the disulfidoptosis-based molecular subtypes. The pathways and immune characteristics of the subtypes were examined via gene set variation analysis, single-sample gene set enrichment analysis, and ESTIMATE. The expression of ke

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12336911 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature