The Adverse Influence of Maternal Glycaemia During Pregnancy on Offspring's Cardiometabolic Health Profiles.

ABSTRACT:

Aim

To describe cardiometabolic health profiles at age 5-6 years, their correlation with age at adiposity rebound (AR) and associations with maternal hyperglycaemia at 24-28 weeks' gestation (gestational diabetes, fasting (FPG), 1-hour postload plasma glucose), in mothers without pre-existing diabetes.

Methods

BMI, %fat mass, blood pressure (BP), FPG, HOMA-IR and lipids were assessed in children from the EDEN study, a French bicentric birth cohort. Sex-specific cardiometabolic health profiles were derived using principal component analysis and examined against age at AR with Pearson's correlation. Associations with maternal hyperglycaemia were studied using multiple linear regressions adjusted for parental factors.

Results

Among 674 children, four profiles were identi

SUBMITTER: Yuan WL 

PROVIDER: S-EPMC12336935 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature