The Excess Polarizability of Single-Stranded DNA Molecules in Solution: A Linear Response Theory in the Polarizable Continuum Model with an Application to Biosensing.

ABSTRACT: The excess polarizability of a molecular solute describes the interaction energy between a molecular solute and a macroscopic optical field that polarizes the solute itself, as compared to the same interaction process involving solvent molecules. The excess polarizability is involved in the physical mechanism that triggers the signals in the whispering gallery mode (WGM), a biosensing technique (denoted as WGM) for detecting biomolecules. The interpretation of the WGM signals requires information on the excess polarizability of the biomolecule of interest, which, until now, could be obtained from experimental measurements of the refractive index of solutions. Here, we present a quantum chemical theory for determining the excess polarizability using the effective linear response theory in t

SUBMITTER: Cammi R 

PROVIDER: S-EPMC12337146 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature