The SAMD1 transcription factor coordinates hematopoietic lineage differentiation and H3K4 methylation status.

ABSTRACT:

Abstract

Cell progenitor to progeny transitions depend on precise transcriptional mechanisms to adjust gene expression. The sterile α-motif-containing 1 protein (SAMD1) regulates a shift in transcriptional activity during embryonic stem cell exit from pluripotency. SAMD1 interacts with, and facilitates the activity of, the histone H3 lysine-specific demethylase 1 (LSD1; a lysine demethylating enzyme). SAMD1 is expressed throughout many biological systems, but its role in hematopoiesis is unknown. In human and mouse hematopoietic stem/progenitor cells, we tested the role of SAMD1 in hematopoiesis and erythropoiesis using loss-of-function approaches. SAMD1 promoted expression of critical drivers of hematopoiesis, including the GATA binding protein 2 transcription factor, while opposi

SUBMITTER: Schaefer MA 

PROVIDER: S-EPMC12337194 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature