Neuronal processes contain the essential components for the late steps of ribosome biogenesis.

ABSTRACT: Neurons rely on spatial and temporal control of protein synthesis to respond rapidly and locally to external stimuli, a process facilitated by the dynamic localization and modification of ribosomes. While previous research has shown that neuronal activity can regulate ribosome localization and modify translation rates, little is known about ribosomal assembly within neuronal processes. Here, we investigated the potential for local ribosome maturation in rat neurons using proteomics, RNA sequencing, and imaging methods. We detected an abundance of ribosome biogenesis factors in distal neuronal compartments, particularly those associated with the late stages of ribosome assembly. Moreover, we detected cytosolic pre-ribosomal RNA species in dendrites, as well as the enzymes necessary for thei

SUBMITTER: Fusco CM 

PROVIDER: S-EPMC12337303 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature