Ultradian rhythms of CRH^PVN neuron activity, behavior, and stress hormone secretion.

ABSTRACT: The stress axis is always active, even in the absence of any threat. This manifests as hourly pulses of corticosteroid stress hormone secretion over the day. Corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus of the hypothalamus (CRH^PVN) control both the neuroendocrine stress axis as well as stress-associated behaviors. However, it is currently unclear how the resting activity of these neurons is coordinated with both spontaneous behavior and ultradian pulses of corticosteroid secretion. To investigate this, we performed fiber photometry recordings of CRH^PVN neuron activity in Crh-Ires-Cre mice and a newly generated line of Crh-Ires-Cre rats. In both mice and rats, CRH^PVN neurons displayed an ultradian rhythm of activ

SUBMITTER: Zheng S 

PROVIDER: S-EPMC12337306 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature