Two-threshold defined immune non-responders are associated with long-term morbidity in people with HIV: a prospective cohort study.

ABSTRACT: A substantial proportion of people with HIV (PWH) fail to achieve full immune recovery despite long-term antiretroviral therapy (ART), potentially increasing their risk of serious comorbidities. This study investigated the association between immune non-responder (INR) and the incidence of AIDS-defining diseases (ADs) and non-AIDS-defining diseases (NADs) in a prospective cohort at the Third People's Hospital of Shenzhen, China. The low - and high-threshold cohorts included 7,874 and 8,077 individuals with baseline CD4⁺ T-cell counts < 350 and < 500cells/μL, respectively. INR was defined as failure to reach CD4⁺ T-cell thresholds (350 or 500 cells/μL) in two consecutive measurements during follow-up. Kaplan-Meier curves and Cox proportional hazards models were used to

SUBMITTER: Li X 

PROVIDER: S-EPMC12337743 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature