Increased expression of the PIEZO2 mechanoreceptor in fibroblasts and endothelial cells within the lymphatic and vascular vessels of keloids.

ABSTRACT: Keloids are scars that grow abnormally due to excessive extracellular matrix production by fibroblasts and increased angiogenesis. Chronic tension is implicated in their growth, but the exact pathology remains unclear. This study investigated the increased expression of molecules responsible for sensing pressure in keloids compared with lymphedema, which is also a non-tumorous fibroproliferative disease caused by another etiology. Higher expression levels of COL1A2, PIEZO2, and POSTN were observed in the keloid group compared with the lymphedema group. PIEZO2 expression levels showed a strong correlation with both COL1A2 (r = 0.9252, 95% CI 0.8474-0.9641, p < 0.001) and POSTN (r = 0.9118, 95% CI 0.8213-0.9575, p < 0.001). Additionally, PIEZO2 expression levels were significantly higher in

SUBMITTER: Akita S 

PROVIDER: S-EPMC12337814 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature