Characterization of H9N2 avian influenza virus isolated from chickens and waterfowl in parts of Southern China from 2018 to April 2024.

ABSTRACT: The H9N2 subtype of avian influenza virus (AIV) has become endemic in poultry farms across China, providing internal genes for other subtypes of viruses and occasionally having the ability to infect humans, thereby posing a significant public health threat. In this study, 61 H9N2 viruses were isolated from chickens and waterfowl in Southern China between 2018 and April 2024. We characterized their genetic derivation, antigenic diversity, receptor-binding specificity, neuraminidase (NA) activity, replication, and transmission in chickens and systematic pathological analysis. Genetic analysis revealed that 60 isolates belonged to the h9.4.2.5 lineage, while 7, 20, and 33 H9 strains belonged to the h9.4.2.5a, b, and c branches, respectively. One isolate belonged to the h9.4.2.1 lineage. Mainl

SUBMITTER: Zhou W 

PROVIDER: S-EPMC12337889 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature