Altered mitochondrial mass and fatty acid uptake by natural killer cells in HIV-exposed uninfected children at 6 years of age.

ABSTRACT:

Background

Cell metabolism is critical for adequate responses by immune cells. Although changes in immune cell populations in uninfected children born to women living with HIV (HEU children) are well described, little is known regarding the metabolic characteristics of their immune cells.

Methods

Peripheral blood mononuclear cells of 110 children at approximately 6 years of age were analysed with flow cytometry to characterize natural killer (NK) cells and measure fatty acid uptake (BODIPY FL C 16 ) and mitochondrial mass [MitoTracker Green (MTG)]. HEU children born to women initiating antiretroviral therapy (ART) during pregnancy [medium-term ART exposure (HEUMT)] ( N  = 30), before conception [long-term ART exposure (HEULT)] ( N  = 39), and 41 HIV-unexposed uninfected (HUU

SUBMITTER: Mataramvura H 

PROVIDER: S-EPMC12337905 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature