Genome-wide association study of angiotensinogen levels and key single nucleotide polymorphism associations with blood pressure.

ABSTRACT:

Objective

The renin angiotensin aldosterone system plays a key role in circulatory homeostasis. We sought to identify genetic determinants of measured plasma angiotensinogen levels and subsequently evaluate the association of these single nucleotide polymorphisms (SNPs) with blood pressure (BP) and hypertension in a multiethnic population.

Methods

Genome-wide association study (GWAS) of plasma angiotensinogen levels, measured using an enzyme-linked immunoassay, was conducted in 4899 Multi-Ethnic Study of Atherosclerosis (MESA) participants (self-identified as White, n = 1865; Hispanic, n  = 1113; Black, n  = 1224; and Chinese, n  = 629). Linear and logistic models examined the association between SNPs with angiotensinogen and hypertension, respectively. Mediation analysis ev

SUBMITTER: Lidani KCF 

PROVIDER: S-EPMC12337919 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature