The natural history of anal high-grade squamous intraepithelial lesions among MSM and transgender women in an acute HIV cohort in Thailand.

ABSTRACT:

Objective

To describe the incidence and clearance rates of anal high-grade squamous intraepithelial lesions (HSIL) among MSM and transgender women who initiated immediate antiretroviral therapy during acute HIV acquisition.

Design

A prospective cohort study of MSM and transgender women diagnosed with acute HIV acquisition in Bangkok, Thailand.

Methods

Participants who were enrolled from May 2017 to June 2020 underwent anal human papillomavirus (HPV) genotyping, high-resolution anoscopy, and anal biopsies as indicated, at baseline and 6-monthly follow-up visits.

Results

Among 89 MSM and 4 transgender women (median age 26 years), the anal HSIL incidence rate was 22.7 per 100 person-years over 180.9 person-years, while the clearance rate was 119.4 per 100 person-y

SUBMITTER: Thitipatarakorn S 

PROVIDER: S-EPMC12337930 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature