Identifying genetic differences between bipolar disorder and major depression through multiple genome-wide association analyses.

ABSTRACT:

Background

Accurate diagnosis of bipolar disorder (BPD) is difficult in clinical practice, with an average delay between symptom onset and diagnosis of about 7 years. A depressive episode often precedes the first manic episode, making it difficult to distinguish BPD from unipolar major depressive disorder (MDD).

Aims

We use genome-wide association analyses (GWAS) to identify differential genetic factors and to develop predictors based on polygenic risk scores (PRS) that may aid early differential diagnosis.

Method

Based on individual genotypes from case-control cohorts of BPD and MDD shared through the Psychiatric Genomics Consortium, we compile case-case-control cohorts, applying a careful quality control procedure. In a resulting cohort of 51 149 individuals (15 532

SUBMITTER: Panagiotaropoulou G 

PROVIDER: S-EPMC12337998 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature