Immune Characterization of a Vietnamese Cohort With Idiopathic Inflammatory Myopathies.

ABSTRACT:

Introduction/aims

Idiopathic inflammatory myopathies (IIMs) are classified into five subtypes that are associated with distinct groups of myositis-specific antibodies (MSAs). Variations in the prevalence, genetic predisposition and clinical manifestations exist in patients with IIM from different ethnic backgrounds. In this study, we aimed to characterize the immunopathological changes in muscle tissue and serum cytokines in a Vietnamese IIM cohort with Kinh ethnicity.

Methods

Muscle biopsies, sera, clinical data, and autoantibody profiles from 64 patients with IIM were included. Muscles were stained by immunohistochemistry using antibodies that target immune cells and molecules. Serum cytokines were measured by multiplex bead arrays. Clustering analysis was performed using

SUBMITTER: Luo YB 

PROVIDER: S-EPMC12338015 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature