End group chemistry modulates physical properties and biomolecule release from biodegradable polyesters.

ABSTRACT: Long-acting injectable protein therapeutics are a rapidly advancing arm of pharmaceuticals. A promising and versatile class of such formulations involves encapsulation of therapeutic protein within poly(lactic-co-glycolic acid) (PLGA) degradable microparticles (MP) to shield the protein from enzymatic degradation and control the release rate. However, models based on degradation and erosion of PLGA polymer matrices do not always fully capture release behavior, due in part to electrostatic interactions between the polymer terminal group and encapsulated compound. The repertoire of functionalized PLGA polymers commercially available has now expanded to include terminal group chemistries that may significantly alter polymer characteristics including charge, hydrophobicity, and erosion.

SUBMITTER: Borrelli MA 

PROVIDER: S-EPMC12338031 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature