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Dopaminergic projections to the prefrontal cortex are critical for rapid threat avoidance learning.

ABSTRACT: To survive, animals must rapidly learn to avoid predictable threats. Such learning depends on detecting reliable cue-outcome relationships that efficiently drive behavioral adaptations. The medial prefrontal cortex (mPFC) integrates learned information about the environment to guide adaptive behaviors¹^,²^,³^,⁴^,⁵^,⁶^,⁷ and is critical for threat avoidance.⁸^,⁹^,¹⁰^,¹¹^,¹²^,¹³^,¹⁴ However, most studies focused on well-learned threat avoidance strategies, and the specific inputs that signal avoidability and drive rapid av

SUBMITTER: Zeidler Z

PROVIDER: S-EPMC12338064 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature

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Dataset Information

Dopaminergic projections to the prefrontal cortex are critical for rapid threat avoidance learning.

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