Adenovirus Remodeling of the Host Proteome and Host Factors Associated with Viral Genomes.

ABSTRACT: Viral infections are associated with extensive remodeling of the cellular proteome. Viruses encode gene products that manipulate host proteins to redirect cellular processes or subvert antiviral immune responses. Adenovirus (AdV) encodes proteins from the early E4 region which are necessary for productive infection. Some cellular antiviral proteins are known to be targeted by AdV E4 gene products, resulting in their degradation or mislocalization. However, the full repertoire of host proteome changes induced by viral E4 proteins has not been defined. To identify cellular proteins and processes manipulated by viral products, we developed a global, unbiased proteomics approach to analyze changes to the host proteome during infection with adenovirus serotype 5 (Ad5) virus. We used whole-cell

SUBMITTER: Dybas JM 

PROVIDER: S-EPMC12338147 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature