Regulatory potency of oligomeric proanthocyanidins (PACs) on extrafibrillar and intrafibrillar collagen mineralization.

ABSTRACT: The therapeutic potential of plant-derived proanthocyanidins (PACs) interacting with mammalian collagen is extensive, notably in strengthening specialized extracellular matrix like the dentin matrix, crucial for reparative dental treatments. This study unveils an additional facet of PACs beyond their recognized chemical and biomechanical advantages in fibrillar collagen: specific tannins possess an inherent capability to influence collagen mineralization. By leveraging the degree of polymerization (DP) of PAC oligomers binding directly to type-I collagen, selective control over in vitro mineralization is achieved. Tetrameric PACs (DP=4) exhibit minimal barriers to extrafibrillar mineralization, whereas dimers (DP=2) effectively hinder nucleation/growth of surface minerals, potentially favo

SUBMITTER: Bim-Junior O 

PROVIDER: S-EPMC12338272 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature