Photoreceptor Disease at Ambiguous Transition Zones in Inherited Retinal Degenerations.

ABSTRACT:

Purpose

Key outcome measures for inherited retinal degenerations (IRDs) are derived from the termination point of the inner and outer segment junction (IS/OS, or ellipsoid zone (EZ)) signal on optical coherence tomography (OCT), which demarcates the emergence of photoreceptor outer segment (OS) abnormalities. However, the termination point is not always abrupt and can be ambiguous. This study aimed to characterize OS disease at each retinal location.

Methods

Widefield OCTs from two ABCA4-associated and fifteen RHO-associated IRD patients were recorded over ∼2 years. Data from a neighborhood of each sample were fed into a two-level artificial intelligence architecture, which achieved 95% accuracy for classifying outer retinal disease into definitely present OS (DPOS), definit

SUBMITTER: Sumaroka A 

PROVIDER: S-EPMC12338365 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature