Photoreceptor Layer Thinning as Biomarker for Circulatory Premature Mortality: UK Biobank Cohort Study.

ABSTRACT:

Purpose

To explore associations between optical coherence tomography (OCT) parameters and mortality risk.

Methods

This study used data from the UK Biobank participants with eligible OCT data. Feature selection was conducted with the least absolute shrinkage and selection operator. Selected parameters were fitted into Cox regression, with the full model adjusting for demographic, socioeconomic, lifestyle, and genetic factors.

Results

During a median follow-up duration of 10.6 years, 3174 were deceased. After matching the deceased and surviving participants (1:3) by age and gender, 12,696 were included. Ten out of 18 parameters showed significant associations with all-cause mortality. Each standard deviation increase in optic disc diameter parameters (hazard ratios [HRs

SUBMITTER: Yusufu M 

PROVIDER: S-EPMC12338373 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature