Direct Activation of Sulfides by C-H Oxidation with Photoexcited Nitroarenes: Formal Manipulations of the C─S Bond.

ABSTRACT: The sulfide motif is distributed widely across chemical and biological space. In synthesis, its installation often marks the end point of a sequence, due to its relative inertness; sulfides typically require direct oxidation of sulfur before they are receptive toward transformation. Unfortunately, selective S-oxidation is not always straightforward, with the need for oxidants lacking chemoselectivity in the presence of functionality and delivering mixtures of oxidation products. This multistep manipulation of the sulfide motif, initiated by direct S-oxidation, limits the use of sulfides as synthetic handles for downstream manipulation. Herein, we describe a direct activation of sulfides by C-H oxidation alpha to sulfur-rather than traditional oxidation at sulfur-that facilitates efficient

SUBMITTER: Cuomo VD 

PROVIDER: S-EPMC12338387 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature