Mechanoactivated Celite as a Catalyst for C‒H Bond Perfluoroalkylation and Other Radical Reactions.

ABSTRACT: Herein, we report that Celite (diatomaceous earth) commonly viewed as an innocent filter aid or support material, or Earth-abundant, non-toxic metal oxides are efficient mechanoactivated catalysts for arene and heteroarene C─H bond radical trifluoromethylation and pentafluoroethylation, with the activity comparable with previously reported mechanochemical methods utilizing piezoelectric materials. Celite was also applied for mechanochemical dibromination of a double bond with N-bromosuccinimide, eliminating the need to use of lithium titanate as a piezoelectric mechanoredox catalyst. Mechanoactivation via ball milling in the presence of minimal amount of solvent was crucial to observe the reactivity, while sonication or using a pre-ground suspension in a bulk solvent were not efficient. Th

SUBMITTER: Hasiweder TJ 

PROVIDER: S-EPMC12338398 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature