Complex Donuts: Small Variations in DNA Sequence Dictate Pathway Complexity in DNA Nanotoroids.

ABSTRACT: The formation of higher-order structures in natural biopolymers, such as polypeptides and nucleic acids, is governed by sequence specificity and monomer chemistry. Although nucleic acids can assemble into programmable nanostructures through base-pairing interactions, their chemical diversity is limited to four nucleobases. DNA amphiphiles overcome this limitation by introducing orthogonal interactions through non-nucleosidic modifications. These amphiphiles self-assemble into diverse morphologies, such as spheres, fibers, or sheets, with closely packed, parallel DNA strands on their exterior. This unusual arrangement can give rise to emergent properties absent in simple DNA strands. Here, we show that the precise sequence of single-stranded DNA, independent of double helix base-pairing, ca

SUBMITTER: Rafique MG 

PROVIDER: S-EPMC12338417 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature