Automated Iterative N─C and C─C Bond Formation.

ABSTRACT: Small molecule solutions to many contemporary societal challenges await discovery, but the artisanal and manual process via which this class of chemical matter is typically accessed limits the discovery of new functions. Automated assembly of (N-methyl iminodiacetic acid) MIDA or (tetramethyl N-methyl iminodiacetic acid) TIDA boronate building blocks via iterative C─C bond formation, an approach we call "block chemistry", alternatively enables generalized and automated preparation of many different types of small molecules in a modular fashion. But in its current form, this engine cannot also leverage nitrogen atoms as iteration handles. Here, we disclose a new iteration-enabling group, CbzT (p-TIDA boronate-substituted carboxybenzyl), that reversibly attenuates the reactivity of nitrogen

SUBMITTER: Tyrikos-Ergas T 

PROVIDER: S-EPMC12338424 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature