Anatomy-to-Tract Mapping: Inferring White Matter Pathways Without Diffusion Streamline Propagation.

ABSTRACT: Diffusion tractography, a cornerstone of white matter mapping, relies on point-to-point streamline propagation-a process often compromised by errors stemming from inadequate signal-to-noise ratio and limited spatioangular resolution in diffusion MRI (dMRI) data. Here, we introduce Anatomy-to-Tract Mapping (ATM), the first model to our knowledge that generates bundle-specific streamlines directly from T1-weighted MRI without requiring orientation field estimation, voxelwise segmentation, and streamline propagation. ATM leverages the superior quality and minimal distortion of anatomical MRI and learns from multi-subject datasets to deliver robust, subject-specific streamline bundles with accurate preservation of structural connectivity. Trained on paired T1w and tractogram data, ATM learns t

SUBMITTER: Tan YF 

PROVIDER: S-EPMC12338524 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature