Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth.

ABSTRACT: Neutrophils are short-lived cells that are produced by the billions every day to circulate throughout the body and surveil all tissues. They are a key component of the innate immune system that play essential roles in antimicrobial immunity, but can also instigate sterile inflammatory diseases like gout and cancer. Immunometabolic paradigms that were developed by studying T cells and macrophages establish that cellular metabolic programming dictates immune function. Neutrophils have long been known as glucose-reliant and highly glycolytic. But surprising neutrophil heterogeneity has recently been described, and roles for lipids have been reported in both granulopoiesis and mature neutrophil effector function. Therefore, we set out to uncover how neutrophils acquire lipids from their enviro

SUBMITTER: Letian A 

PROVIDER: S-EPMC12338532 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature