From 2D to 4D: a Containerized Workflow and Browser to Explore Dynamic Chromatin Architecture.

ABSTRACT:

Background

Characterizing the physical organization of the genome is essential for understanding long-range gene regulation, chromatin compartmentalization, and epigenetic accessibility. Hi-C experiments generate two-dimensional (2D) genome-wide contact maps of chromatin interactions by capturing the spatial proximity between genomic loci, which reveal interaction frequencies but lack the spatial resolution needed to interpret the three-dimensional (3D) genome structure(s). Emerging evidence suggests that epigenetic regulation is closely linked to 3D genome architecture, and that structural changes over time (4D) drive key biological processes in development, disease, and environmental response. Thus, integrating 3D structure with functional data is critical for a more complete und

SUBMITTER: Rogers DH 

PROVIDER: S-EPMC12338655 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature