Characterization of a Novel Transmembrane Activating STING Agonist using Genetically Humanized Mice.

ABSTRACT: STING is a pattern recognition receptor that activates type I interferon and proinflammatory responses in addition to unrelated molecular processes following exposure of DNA to the cytosol. Its pharmacologic stimulation enhances vaccine potency and generates effective antitumor responses but clinical trials evaluating STING agonists have not led to approval for human use. STING activation can occur through ligand engagement of either cytosolic or transmembrane protein domains, processes to which distinct cellular phenotypes are attributed. However, the only transmembrane STING agonist identified is human selective and in vivo testing in conventional models is not feasible. Here we describe synthesis of novel STING agonists efficacious against allelic variants of the protein. We also

SUBMITTER: Mizuno N 

PROVIDER: S-EPMC12338696 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature