The Rab32-LRMDA-Retriever Complex is a Key Regulator of Intestinal Immune Homeostasis.

ABSTRACT: Maintaining intestinal homeostasis relies on the intricate interplay among the mucosal epithelium, immune system, and host microbiome. A key question is how innate immune cells sense and process microbes in the gut lumen, eliciting appropriate protective responses without causing tissue injury. Clearance of invading microbes and initiation of downstream inflammatory responses are central to this process and require proper function of the endolysosomal system. Dysfunction of this system can predispose the host to chronic inflammatory disorders and acute infections. Here, through forward genetic screening of N-ethyl-N-nitrosourea (ENU)-mutagenized mice and CRISPR/Cas9 validation, we identify Lrmda, encoding leucine-rich melanocyte differentiation-associated protein (LRMDA), as a key r

SUBMITTER: Song R 

PROVIDER: S-EPMC12338710 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature