Intracellular replication dynamics of influenza A virus impose strong bottleneck effects.

ABSTRACT: Understanding the sources of genetic diversity in Influenza A Virus (IAV) infections is crucial for understanding the mechanisms of viral evolution and immune escape. Whereas prior studies have characterized the effects of population bottlenecks during host-to-host transmission and intrahost tissue-to-tissue dissemination, the role of intracellular replication processes on IAV genetic diversity remains largely unexplored. In this study, we used stochastic mathematical modeling to simulate the replication of genetically distinct IAV strains within individual cells and tissues. Our results reveal significant bottleneck effects within a single infection cycle of individual cells. Intracellular bottleneck effects are driven by stochastic molecular processes and lead to the expansion or elimina

SUBMITTER: Segredo-Otero EA 

PROVIDER: S-EPMC12338728 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature