Human cortex organizes dynamic co-fluctuations along sensation-association axis.

ABSTRACT: The human brain dynamically organizes its activity through coordinated fluctuations, whose spatiotemporal interactions form the foundation of functional networks. While large-scale co-fluctuations are well-studied, the principles governing their amplitude-dependent transitions--particularly across high, intermediate, and low-amplitude regime--remain unknown. We introduce a co-fluctuation score to quantify how instantaneous functional interactions reorganize with global amplitude dynamics. Using resting-state fMRI data, we identified amplitude-dependent co-fluctuation transitions between functional systems hierarchically aligned with the sensorimotor-association (SA) axis: sensorimotor networks dominated high-amplitude co-fluctuations, associative systems prevailed during intermediate ampli

SUBMITTER: Jin DZ 

PROVIDER: S-EPMC12338729 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature