Toward optimized intravoxel incoherent motion (IVIM) and compartmental T2 mapping in abdominal organs.

ABSTRACT:

Purpose

To quantitatively assess the bias in the intravoxel incoherent motions (IVIM)-derived pseudo-diffusion volume fraction (f) caused by the differences in relaxation times between the tissue and fluid compartments, and to develop a 2D fitting approach and an optimal acquisition protocol for the relaxation compensated T2-IVIM imaging in the liver and kidney.

Methods

Numerical simulations were conducted to investigate the TR- and TE-dependent bias in f when using the conventional IVIM model, and to evaluate the applicability of the extended 2D T2-IVIM model for reducing this bias. The in silico findings were then validated using the in vivo IVIM data from healthy volunteers on a clinical 3-Tesla MRI scanner. Finally, a numerical framework for o

SUBMITTER: Stabinska J 

PROVIDER: S-EPMC12338893 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature