Global effects in fMRI reveal brain markers of state and trait anxiety.

ABSTRACT:

Background

To personalize the diagnosis and treatment of anxiety, there is a need to identify biological constructs that underlie self-reported symptoms. Notably, physiological responses and altered levels of arousal are constituents of anxiety and have widespread ("global") effects on fMRI signals across the brain. Therefore, fMRI signatures of global cortical arousal and autonomic physiological responses may provide valuable neuroimaging biomarkers of anxiety. Additionally, these effects may also contribute to relationships observed between large scale network dynamics and anxiety level.

Methods

Drawing upon data from a large community sample of 543 subjects (F=369, M=174) we examine whether the global mean fMRI signal, and a data-driven estimate of cortical arousal effect

SUBMITTER: Rogge-Obando K 

PROVIDER: S-EPMC12338923 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature