Altered striatal functional gradients in obsessive-compulsive disorder.

ABSTRACT:

Background

Obsessive-compulsive disorder (OCD) is associated with functional alterations in how the striatum interacts with the rest of the brain. However, the characterization of these changes in OCD is incomplete. Mapping functional striatal gradients provides a new opportunity to fill this knowledge gap. These gradients provide a spatial representation of continuous changes in whole-brain connectivity within striatal regions. Thus, OCD-related differences in striatal gradients imply changes in the functional organisation of striatal connections.

Methods

We calculated spatial striatal gradients linked to whole brain activity in 52 people with OCD and 45 controls. Gradients were computed with individuals at rest and when they underwent a threat-safety reversal task. Using a

SUBMITTER: Webb L 

PROVIDER: S-EPMC12338943 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature