Genotype-phenotype association study conducted on LARGE-PD reveals novel loci associated with Parkinson's Disease.

ABSTRACT:

Background

The Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD) is a multicenter collaboration aimed at understanding the genetic architecture of Parkinson's disease (PD) in this underrepresented population using data from 15 countries across the Americas and the Caribbean. In this study, we conducted the largest genome-wide association studies (GWAS) for PD susceptibility in Latin Americans.

Methods

We analyzed genotype data from LARGE-PD Phase 1 (n = 1,498) and Phase 2 (n = 4,401) using multiple GWAS approaches: SAIGE, which incorporates a genetic relationship matrix in the model; ATT, which includes global ancestry on the model; TRACTOR, which splits allele dosages by ancestry to detect ancestry-specific risk loci; and admixture mapping

SUBMITTER: Leal TP 

PROVIDER: S-EPMC12338945 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature