The impact of ancestry on performance of type 1 diabetes genetic risk scores: high discrimination performance is maintained in African ancestry populations, but population specific thresholds may improve risk prediction.

ABSTRACT:

Objective

Genetic risk scores (GRSs) for type 1 diabetes (T1D) may assist T1D classification and prediction but are often developed from European populations. To improve health outcomes, it is important to understand the performance and utility of GRSs in diverse ancestry populations.

Research design and methods

We assessed performance of three previously published T1D GRSs in differentiating people with and without Type 1 diabetes in African (with/without T1D=194/235), European (n=1109/125), and Hispanic (266/170) ancestry populations in the USA, and from Cameroon and Uganda (n=144/5001). The assessed GRSs were developed from European ancestry populations (GRS1, GRS2) and from an African ancestry population (AAGRS).

Results

The discriminative power, as measured by th

SUBMITTER: Squires S 

PROVIDER: S-EPMC12338948 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature