Young microbiome transplantation enhances recovery after myocardial infarction.

ABSTRACT:

Background

The relationship between aging, gut microbiota, and cardiac repair after myocardial infarction (MI) remains unclear. Understanding this interaction may provide novel strategies for improving cardiovascular outcomes in the elderly.

Methods

Aged mice were treated with antibiotics followed by fecal microbiota transplantation (FMT) from young or aged donors prior to MI. Cardiac function, gut integrity, immune signaling, and metabolism were evaluated. Gut microbiota and plasma metabolites were also profiled in ST-elevation myocardial infarction (STEMI) patients across age groups.

Results

Young FMT improved post-MI cardiac function and reduced infarct size in aged mice. It preserved intestinal barrier integrity, reduced IL-17A-positive immune cells, and attenuate

SUBMITTER: You MY 

PROVIDER: S-EPMC12339018 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature