The influence of cancer on a forensic age estimation tool.

ABSTRACT: The use of epigenetic clocks for measuring age acceleration in the field of cancer research has been a common practice for many years. In forensic genetics, DNA methylation can be used to estimate the age of a stain donor. As lifestyle and disease can alter a person's methylation profile, the accuracy of forensic age estimation tools might decrease compared to the chronological age when estimating a person affected by cancer. In our study, we applied the VISAGE enhanced age estimation tool on blood samples from cancer patients suffering from a variety of cancer entities, including solid and hematologic tumours. A comparison of the age estimation errors between the cancer patients (n = 100) and a healthy control cohort (n = 102) revealed small statistically significant differences and a ten

SUBMITTER: Sutter C 

PROVIDER: S-EPMC12339023 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature