Exploring molecular links between obesity and osteoporosis: insights from in-silico analysis and mannose supplementation.

ABSTRACT: D-mannose, a plant-derived monosaccharide used as a dietary supplement, has shown potential in alleviating obesity symptoms and improving bone loss in mice. Obesity, a known risk factor for osteoporosis (OP), suggests shared molecular pathways between these conditions. This study explores the molecular mechanisms of obesity-induced OP and the potential therapeutic role of mannose supplementation. Using in-silico analysis, GEO2R was applied to dataset GSE110796 to identify differentially expressed genes (DEGs) under high-fat diet-induced obesity and mannose supplementation. Enrichment analysis via Enrichr and ClueGO revealed significant molecular pathways altered by high-fat diets and reversed by mannose. Similarly, pathways for OP were identified using the GEO dataset GSE56815 and DisGeNET

SUBMITTER: James R 

PROVIDER: S-EPMC12339693 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature