Fatty acid amide hydrolase in major depressive episodes: A [¹¹C]CURB positron emission tomography study.

ABSTRACT: The role of the endocannabinoid system (ECS) in major depressive disorder (MDD) is under-investigated despite reports of increased activity and/or concentration of fatty acid amide hydrolase (FAAH), a key ECS enzyme, in fronto-limbic brain regions in some animal models of depressive behavior. We hypothesized that [¹¹C]CURB λk₃, an index of FAAH density, would be elevated in the prefrontal cortex, hippocampus, and anterior cingulate cortex in major depressive episodes of MDD compared to healthy controls. Fifteen unmedicated MDD participants and 15 age- and sex-matched healthy controls underwent [¹¹C]CURB positron emission tomography and FAAH genotyping. Psychological tests of depressive severity, apathy, and anxiety were administered and measurements were as

SUBMITTER: Rafiei D 

PROVIDER: S-EPMC12339711 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature