Theta-phase locking of single neurons during human spatial memory.

ABSTRACT: Memory processes may rely on complex interactions between single-neuron activity and local field potentials. To better understand such spike-field relationships in humans, we examined human theta-phase locking-neuronal firing at similar theta phases over time-using single-neuron recordings in epilepsy patients performing a spatial memory task. Applying frequency-adaptive theta-phase estimation in a broad 1-10 Hz frequency range, we found that theta-phase locking was widespread in the human medial temporal lobe during memory encoding and retrieval. Time-resolved spectral parameterization and cycle-by-cycle analysis demonstrated stronger theta-phase locking during steep aperiodic slopes and prominent theta oscillations. Phase-locking strength was similar across successful and unsuccessful me

SUBMITTER: Guth TA 

PROVIDER: S-EPMC12339722 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature