Stability of Ceftobiprole Medocaril in Portable Elastomeric Infusion Devices.

ABSTRACT:

Introduction

Ceftobiprole medocaril is a new fifth-generation cephalosporin commercially available as a prodrug. Since it is newly introduced in therapy, there is limited data on its physicochemical stability for outpatient parenteral antimicrobial therapy (OPAT). This work aimed to demonstrate the suitability of ceftobiprole medocaril in OPAT, determining the physicochemical stability within portable elastomeric infusion devices (Accufuser C0100L 10 mL/h 300 mL).

Methods

Physicochemical stability was evaluated in 6.25 mg/mL solutions in sodium chloride 0.9% and dextrose 5% at three temperatures (2-8 °C, 25 °C, and 32 °C) using a previously validated liquid chromatography triple quadrupole mass spectrometry (LC-QQQ-MS) method. Drug adsorption onto device walls was also deter

SUBMITTER: Esteban-Cartelle B 

PROVIDER: S-EPMC12339844 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature