Exploration of autophagy-associated genes and potential molecular mechanisms in type 1 diabetes and osteoporosis.

ABSTRACT: The co-occurrence of osteoporosis (OP) and type 1 diabetes mellitus (T1DM) represents a clinically significant comorbidity pattern, characterized by skeletal fragility and insulin deficiency. While epidemiological links exist, their shared molecular mechanisms remain undefined. This study investigates autophagy-a critical cellular degradation pathway-as a potential mechanistic bridge between OP and T1DM pathogenesis. We integrated multi-omics approaches using GEO datasets to identify autophagy- associated hub genes. Machine learning (LASSO/Random Forest) prioritized CPNE1 and FRAT2, validated through ROC curve analysis. Functional annotation via GO/KEGG enrichment analyses revealed enrichment in disease-associated pathways, corroborated by immune infiltration profiling and single-cell RNA

SUBMITTER: Wang H 

PROVIDER: S-EPMC12340000 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature