The association between red blood cell transfusion timing and the development of retinopathy of prematurity: Application of the two-phase theory.

ABSTRACT:

Purpose

Red blood cell (RBC) transfusions are believed to be associated with retinopathy of prematurity (ROP), but the underlying mechanism is not fully understood, partly due to the lack of information on RBC transfusion timing. The aim was to determine the association between the timing and amount of RBC transfusions and the development and severity of ROP.

Methods

This retrospective dual-center cohort study included 1177 neonates born in 2004-2022 with a gestational age at birth ≤28 weeks. Primary outcomes were any stage ROP and severe ROP based on maximum staging. Phase I of ROP was defined as ≤32.0 weeks postmenstrual age and phase II as >32.0 weeks postmenstrual age. Logistic regression analyses were adjusted for gestational age at birth, small for gestational age, mec

SUBMITTER: El Emrani S 

PROVIDER: S-EPMC12340170 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature