Effectiveness and safety of sirolimus in the treatment of venous malformations: A meta-analysis of prospective studies.

ABSTRACT:

Background

Venous malformations are prevalent vascular anomalies. Recent clinical studies have explored the use of sirolimus for these conditions, particularly in patients who are not candidates for, or have shown limited response to, traditional treatments such as sclerotherapy and surgery. This meta-analysis systematically evaluates the efficacy and safety of sirolimus in treating venous malformations.

Methods

We conducted searches in PubMed, Cochrane Library, Web of Science, and the Cochrane Database of Systematic Reviews until August 10, 2024. The quality of the included prospective studies (including both randomized and single-arm pre-post trials) was assessed using the Cochrane risk of bias tool. Statistical analyses were performed with Review Manager (Version 5.4).

SUBMITTER: Wang G 

PROVIDER: S-EPMC12340385 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature