Classifying mild cognitive impairment from normal cognition: fMRI complexity matches tau PET performance.

ABSTRACT:

Introduction

Cognitive decline in Alzheimer's disease (AD) is closely linked to tau pathology, which leads to loss of synaptic connections and ultimately neurons. While tau positron emission tomography (PET) carries radiation risks, is costly, and often unavailable in clinical settings, brain entropy mapping via resting-state functional magnetic resonance imaging (fMRI) has emerged as a marker of impaired brain function related to tauopathy.

Methods

Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and Estudio de la Enfermedad de Alzheimer en Jalisciences (EEAJ), we investigate the classification performance of fMRI entropy with tau PET in distinguishing cognitively normal (CN) from cognitively impaired (mild cognitive impairment/AD) individuals. Convolu

SUBMITTER: Jann K 

PROVIDER: S-EPMC12340428 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature