Effect of Dual Bronchodilation on the Exercise Capacity of Individuals With Non-Cystic Fibrosis Bronchiectasis: Protocol for a Randomized Controlled Double-Blind Crossover Study.

ABSTRACT:

Background

Bronchodilators (BDs) have been used therapeutically to improve exercise capacity in patients with other chronic respiratory diseases. However, the effect of BDs on the exercise capacity of individuals with non-cystic fibrosis bronchiectasis (NCFB) is poorly understood.

Objective

The aim of this study was to evaluate the effects of BDs on exercise capacity and thoracoabdominal kinematics in patients with NCFB.

Methods

This crossover randomized controlled trial will involve 45 outpatients with NCFB aged 18 to 59 years. They will be evaluated in 3 visits. On day 1, the maximal exercise capacity (cardiopulmonary exercise test; peak work rate [W_peak]) will be assessed. On day 2, individuals will be randomized to receive either BD (ipratropium bromide

SUBMITTER: Marques da Silva CCB 

PROVIDER: S-EPMC12340461 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature